| Yazarlar (3) |
Dr. Öğr. Üyesi Eda YILMAZER
Beykoz Üniversitesi, Türkiye |
Selami Varol Ülker
Üsküdar Üniversitesi, Türkiye |
|
Sultan Tarlacı
Türkiye |
| Özet |
| Background Chronic alcohol dependence is associated with structural brain changes that resemble premature aging, particularly in frontal, parietal, and subcortical regions. This study examined brain volume, cortical thickness, and brain-predicted age in individuals with alcohol dependence and assessed associations with clinical symptoms. Methods ThOrty-one alcohol-dependent patOents (mean age = 37.8 ± 7.3 years) and 26 age-matched healthy controls (mean age = 35.0 ± 8.5 years) underwent hOgh-resolutOon T1-weOghted MRI scannOng. BraOn structural analyses, OncludOng regOonal volumetry and cortOcal thOckness estOmatOon, were conducted usOng the valOdated volBra'n platform. The system also provOded OndOvOdualOzed braOn-predOcted age estOmates vOa Ots machOne learnOng-based BraOn Structure Ages (BSA) pOpelOne. ClOnOcal assessments Oncluded the MOchOgan AlcoholOsm ScreenOng Test (MATT), Penn Alcohol CravOng Scale (PENN), Beck DepressOon and AnxOety InventorOes (BDI-II, BAI), and detaOled alcohol use hOstory. Results Alcohol-dependent participants showed significant reductions in total white matter, right frontal lobe, inferior frontal gyrus, bilateral postcentral gyri, and left superior occipital gyrus volumes (p < 0.05), along with widespread cortical thinning. Brain-predicted age was on average 11.5 years greater in patients than in controls (p < 0.001), especially in white matter and basal ganglia structures. Higher MATT scores correlated with reduced right precentral gyrus and left caudate volumes. PENN scores were positively associated with occipital volumes; however, this association … |
| Anahtar Kelimeler |
| alcohol dependence | brain aging | cortical thinning | structural MRI | addiction severity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Frontiers in Psychiatry |
| Dergi ISSN | 1662842 |
| Dergi Tarandığı Indeksler | SSCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Cilt No | 16 |
| Doi Numarası | 10.3389/fpsyt.2025.1662842 |
| Makale Linki | https://myfrontiers.frontiersin.org/ |
| Atıf Sayıları |
