| Yazarlar (3) |
Dr. Öğr. Üyesi Eda YILMAZER
Beykoz Üniversitesi, Türkiye |
Sultan Tarlacı
Üsküdar Üniversitesi, Türkiye |
|
Selami Varol Ülker
Üsküdar Üniversitesi, Türkiye |
| Özet |
| Background: Theta-band cordance is a quantitative EEG (qEEG) metric that integrates absolute and relative spectral power and correlates with regional cerebral perfusion. Although widely applied in psychiatric and neurophysiological research, its longitudinal trajectory in healthy adults remains largely unknown. This study aimed to characterize multi-year changes in theta cordance across cortical regions, determine which areas show stability versus decline, and evaluate whether individuals maintain a trait-like cordance profile over time. Methods: Nineteen cognitively healthy, medication-free adults underwent resting-state EEG recordings at two time points, separated by an average of 6.4 years (range: 1.9–14.8). Theta cordance (4–8 Hz) was computed at 19 scalp electrodes using the Leuchter algorithm and aggregated into eight lobar regions (left/right frontal, temporal, parietal, occipital). Paired-samples t-tests assessed longitudinal changes. Inter-regional Pearson correlations examined evolving connectivity patterns. Canonical correlation analysis (CCA), validated via LOOCV and bootstrap confidence intervals, evaluated multivariate stability between baseline and follow-up cordance profiles. Results: Theta cordance remained normally distributed at both time points. Significant longitudinal decreases emerged in the right temporal (t(18) = 5.34, p < 0.001, d = 1.23) and right frontal (t(18) = 2.65, p = 0.016, d = 0.61) regions, while other lobes showed no significant change. Midline Cz demonstrated a robust increase over time (p < 0.001). CCA revealed a strong cross-time association (Rc = 0.999, p = 0.029), indicating preservation of a stable … |
| Anahtar Kelimeler |
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Clinical Medicine |
| Dergi Tarandığı Indeksler | SSCI |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2025 |
| Cilt No | 14 |
| Sayı | 8341 |
| DOI Numarası | 10.3390/jcm14238341 |
| Makale Linki | https://www.mdpi.com/2077-0383/14/23/8341 |
| Atıf Sayıları |
