| Yazarlar (7) |
Ersi Abaci Kalfoglu
Istanbul Üniversitesi, Türkiye |
|
Reza Dashti
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye |
|
Gabriel Petridis
Istanbul Üniversitesi, Türkiye |
|
E. Hulya Yukseloglu
Istanbul Üniversitesi, Türkiye |
|
S. Sebnem Ozcan
Istanbul Üniversitesi, Türkiye |
Prof. Dr. Mansur BEYAZYÜREK
Balikli Greek Hospital, Türkiye |
|
Sevil Atasoy
Istanbul Üniversitesi, Türkiye |
| Özet |
| Drug addiction is characterized by impairment of reward, compulsive behavior and inhibitory control deficits. Addiction genetic studies are focused on identifying the candidate genes responsible for the disease. However studies performed in different populations reveal different and sometimes conflicting results. In this study we aimed to determine the association of dopamine DRD3 receptor gene polymorphism and drug addiction in Turkish population. The patient group included 126 addicts diagnosed according to DSM-IV criteria. The results were compared to 100 individuals with no history of addiction. The gene frequencies were tested with Hardy-Weinberg equilibrium. Socio-demographic data including educational level, marital status and occupation were also evaluated. The frequencies of A1 homozygote individuals were 46%, A1 and A2 heterozygotes were 41.6% and A2 homozygotes were 12.7%, while they were respectively 46%, 43% and 11% in controls. According to the overall results, no statistically significant difference in DRD3 polymorphism was observed between the patient and control groups. There was a slight but significant association between DRD3 receptor gene, heroin and cocaine addiction, which was found to be consistent with some of the literature. © 2009 Elsevier Ireland Ltd. All rights reserved. |
| Anahtar Kelimeler |
| Addiction | Dopamine | DRD3 | Polymorphism | Turkey |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | Forensic Science International Genetics Supplement Series |
| Dergi ISSN | 1875-1768 Wos Dergi Scopus Dergi |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2009 |
| Cilt No | 2 |
| Sayı | 1 |
| Sayfalar | 489 / 490 |
| DOI Numarası | 10.1016/j.fsigss.2009.09.013 |
| Makale Linki | http://www.fsigeneticssup.com/article/S1875176809002212/pdf |
| Atıf Sayıları |
