Salivary Oxytocin Levels in Children with and Without Autism: Group Similarities and Subgroup Variability
Yazarlar (5)
Dr. Öğr. Üyesi Eda YILMAZER Beykoz Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metin Çınaroğlu İstanbul Nişantaşı Üniversitesi, Türkiye
Öğr. Gör. Salih Köse Üsküdar Üniversitesi
Dr. Öğr. Üyesi Selami Varol Ülker Üsküdar Üniversitesi, Türkiye
Prof. Dr. Sultan Tarlacı Üsküdar Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | JOURNAL OF CLINICAL MEDICINE (Q1) | ||
| Dergi ISSN | 2077-0383 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2025 |
| Cilt / Sayı / Sayfa | 14 / 19 / 6760–0 | DOI | 10.3390/jcm14196760 |
| Makale Linki | https://www.mdpi.com/2077-0383/14/19/6760 | ||
| UAK Araştırma Alanları |
Sosyal Psikiyatri ve Toplum Ruh Sağlığı
Nöropsikoloji
Sağlık Psikolojisi
|
||
| Özet |
| Background Oxytocin (OXT), a neuropeptide involved in social bonding, has been proposed as a potential biomarker for autism spectrum disorder (ASD) due to its role in modulating social behaviors. However, prior studies on peripheral OXT levels in individuals with ASD have yielded inconsistent results, partly due to methodological and developmental variability. This study aimed to compare baseline salivary OXT concentrations between children with ASD and typically developing controls. Methods In this cross-sectional, case–control study, salivary OXT levels were measured in 35 children aged 6–9 years (18 with ASD, 17 controls) using a standardized ELISA protocol. Samples were collected under controlled conditions and analyzed in duplicate. Between-group differences in raw and log-transformed OXT levels were examined using t-tests. Subgroup analyses were conducted by sex, and correlations with autism symptom severity (Aberrant Behavior Checklist, ABC) were assessed within the ASD group. Results Children with ASD showed higher mean salivary OXT levels than controls (21.5 pg/mL vs. 14.0 pg/mL), but the difference was not statistically significant (Welch’s t = −1.79, p = 0.088). Log transformation of OXT values confirmed the non-significant group difference (t = 1.68, p = 0.102). Female participants with ASD had significantly higher OXT than female controls (p = 0.048), while no difference was observed among males. OXT levels did not significantly correlate with autism severity (r = −0.04, p = 0.88). Conclusions Baseline salivary OXT levels do not significantly differ between children with and without ASD and do not correlate … |
| Anahtar Kelimeler |
| autism spectrum disorder | oxytocin | saliva | biomarker | children | ELISA |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Google Scholar | 2 |