| Yazarlar (8) |
Pınar Kurt
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Derya Durusu Emek
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Kübra Batum
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Gölbaşı Bilge Turp
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Bahar Güntekin
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Sibel Karşıdağ
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Erol Başar
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Görsev Yener
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| Özet |
| Background Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory eventrelated delta oscillations of MCI subjects. Method The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age- and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F3, Fz, F4, C3, Cz, C4, P3, Pz, P4, O1, Oz, and O2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2 Hz) were measured. Results The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls than MCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F3, Fz, F4, Cz, C4, and Pz. Discussion Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies. |
| Anahtar Kelimeler |
| Bildiri Türü | Tebliğ/Bildiri |
| Bildiri Alt Türü | Poster Olarak Sergilenen Tebliğ (Uluslararası Kongre/Sempozyum) |
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum |
| Bildiri Dili | İngilizce |
| Kongre Adı | 67th Annual Scientific Convention ad Meeting of the Society-of-Biological-Psychiatry |
| Kongre Tarihi | 03-05-2012 / 05-05-2012 |
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