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Görsev Yener
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Müslüm Yılmaz
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Meral Oğuz
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| Özet |
| Background Alzheimer's disease (AD) is a common neurodegenerative disease that affects cognitive functions in the absence of motor signs. However, motor associated functional cortical changes mirror the changes of cognitive network in AD patients. The movement related cortical potentials (MRCP) can be used to investigate the cognitive processes prior to voluntary movement. The neuropsychological deficits that implicate disruption of involving frontal motor network in early AD would also cause alterations in all phases of MRCP. The present study aimed to investigate whether such changes occur in MRCPs of AD patients. Methods MRCP of twenty-three mild probable AD and twenty healthy, education-, genderand age-matched control subjects were studied. Results AD patients differed from healthy control subjects on mini mental state examination (MMSE), both verbal and visual memory, verbal fluency, executive function and visuo-spatial test scores. AD patients showed significant changes in both early and late phases of Bereitshaftspotential (BP) than controls. Diminished amplitude and less preparation time for movement in MRCP recordings along with executive dysfunction were found. Conclusion These findings seem to reflect the disruption of frontal motor network during movement preparation in AD and may correspond to a loss of motor preplanning caused by deranged neuronal input into supplementary motor area (SMA). |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Neurological Sciences [Turkish] |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2010 |
| Cilt No | 27 |
| Sayı | 2 |
| Sayfalar | 150 / 159 |
