| Yazarlar (10) |
Merve Ekin
|
|
Koray Koçoğlu
Türkiye |
|
Hatice Eraslan Boz
İzmir Demokrasi Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Müge AKKOYUN
|
|
Işıl Yağmur Tüfekci
|
|
Ezgi Cesim
|
|
Berna Yalınçetin
|
|
Simge Uzman Özbek
Türkiye |
|
İbrahim Emre Bora
Türkiye |
|
Gülden Akdal Halmagyı
Dokuz Eylül Üniversitesi, Türkiye |
| Özet |
| Ultra-high-risk for bipolar disorder (UHR-BD) is an important paradigm to investigate the potential early-stage biomarkers of bipolar disorder, including eye-tracking abnormalities and cognitive functions. Antisaccade (AS) described as looking in the opposite direction of the target, and memory-guided saccade (MGS), identified as maintaining fixation, and remembering the location of the target, were used in this study. The aim of this study was to evaluate the differences in saccadic eye movements between UHR-BD and healthy controls (HCs) via AS-MGS. The study included 28 UHR-BD and 29 HCs. Participants were selected using a structured clinical interview for prodromal symptoms of BD. AS-MGS were measured with parameters like uncorrected errors, anticipatory saccades, and latency. Eye movements were recorded with the EyeLink 1000-Plus eye-tracker. In the AS, the number of correct saccades was significantly decreased in UHR-BD (p = 0.020). Anticipatory (p = 0.009) and express saccades (p = 0.040) were increased in UHR-BD. In the MGS paradigm, the correct saccades were reduced in UHR-BD (p = 0.031). In addition, anticipatory (p = 0.004) and express saccades (p = 0.012) were significantly increased in cue-screen in UHR-BD. To our knowledge, this is the first study to evaluate cognitive functions with eye movements in individuals at UHR-BD. The current findings showed that eye movement functions, particularly in saccadic parameters related to inhibition and spatial perception, may be affected in the UHR-BD group. Therefore, assessment of oculomotor functions may provide observation of clinical and cognitive functions in the early-stage of bipolar disorder. However, further research is needed because the potential effects of medication may affect saccadic results. |
| Anahtar Kelimeler |
| Antisaccade | Memory-guided saccade | Ultra -high risk | Bipolar disorder |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of affective disorders |
| Dergi ISSN | 0165-0327 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2023 |
| Cilt No | 339 |
| Sayfalar | 965 / 972 |
| Doi Numarası | 10.1016/j.jad.2023.07.109 |
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 5 |
