Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism
 
Yazarlar (6)
Ümit Mutlu-Türkoǧlu
Istanbul Üniversitesi, Türkiye
Semra Doǧru-Abbasoǧlu Istanbul Üniversitesi, Türkiye
Gülçin Aykaç-Toker Istanbul Üniversitesi, Türkiye
Hasan Mirsal Istanbul Üniversitesi, Türkiye
Prof. Dr. Mansur BEYAZYÜREK Istanbul Üniversitesi, Türkiye
Müjdat Uysal Istanbul Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Laboratory and Clinical Medicine (Q4)
Dergi ISSN 0022-2143
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 10-2000
Cilt / Sayı / Sayfa 136 / 4 / 287–291 DOI 10.1067/mlc.2000.109097
Makale Linki https://linkinghub.elsevier.com/retrieve/pii/S0022214300393015
UAK Araştırma Alanları
Ruh Sağlığı ve Hastalıkları
Özet
Increased oxidative stress has been speculated to be one possible mechanism of ethanol toxicity. This study evaluates malondialdehyde (MDA) and protein carbonyl content in serum as markers of oxidative stress and DNA damage in lymphocytes in the same patients with chronic alcoholism. Patients with chronic alcoholism showed a significant increase in MDA levels and protein carbonyl content of their serum as compared with non-alcoholic control subjects. Increases in endogenous and H2O2-induced DNA damage were also observed in lymphocytes of patients with chronic alcoholism. In addition, there were significant correlations between endogenous and H2O2-induced DNA damage and serum MDA or protein carbonyl content in patients with chronic alcoholism. These results clearly indicate the presence of oxidative stress in patients with chronic alcoholism.
Anahtar Kelimeler
Science Direct
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Scopus 67
Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism

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