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Akademisyenler > Mansur BEYAZYÜREK > Yayın Detayı

Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism    
Yazarlar (6)
Ümit Mutlu-Türkoǧlu
Istanbul Üniversitesi, Türkiye
Semra Doǧru-Abbasoǧlu
Istanbul Üniversitesi, Türkiye
Gülçin Aykaç-Toker
Istanbul Üniversitesi, Türkiye
Hasan Mirsal
Istanbul Üniversitesi, Türkiye
Prof. Dr. Mansur BEYAZYÜREK Prof. Dr. Mansur BEYAZYÜREK
Istanbul Üniversitesi, Türkiye
Müjdat Uysal
Istanbul Üniversitesi, Türkiye
Devamını Göster
Özet
Increased oxidative stress has been speculated to be one possible mechanism of ethanol toxicity. This study evaluates malondialdehyde (MDA) and protein carbonyl content in serum as markers of oxidative stress and DNA damage in lymphocytes in the same patients with chronic alcoholism. Patients with chronic alcoholism showed a significant increase in MDA levels and protein carbonyl content of their serum as compared with non-alcoholic control subjects. Increases in endogenous and H2O2-induced DNA damage were also observed in lymphocytes of patients with chronic alcoholism. In addition, there were significant correlations between endogenous and H2O2-induced DNA damage and serum MDA or protein carbonyl content in patients with chronic alcoholism. These results clearly indicate the presence of oxidative stress in patients with chronic alcoholism.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Journal of Laboratory and Clinical Medicine
Dergi ISSN 0022-2143
Dergi Tarandığı Indeksler SCI
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 10-2000
Cilt No 136
Sayı 4
Sayfalar 287 / 291
DOI Numarası 10.1067/mlc.2000.109097
Science Direct
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
SCOPUS 67
Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism

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