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Akademisyenler > Mansur BEYAZYÜREK > Yayın Detayı

Increased LDLVLDL oxidizability and plasma homocysteine levels in chronic alcoholic patients   
Yazarlar (7)
Jale Balkan
İstanbul Tıp Fakültesi, Türkiye
Pervin Vural
İstanbul Tıp Fakültesi, Türkiye
Serdar Öztezcan
İstanbul Tıp Fakültesi, Türkiye
Hasan Mirsal
Balikli Rum Hastanesi Vakfi, Türkiye
Prof. Dr. Mansur BEYAZYÜREK Prof. Dr. Mansur BEYAZYÜREK
Balikli Rum Hastanesi Vakfi, Türkiye
Gülçin Aykaç-Toker
İstanbul Tıp Fakültesi, Türkiye
Müjdat Uysal
İstanbul Tıp Fakültesi, Türkiye
Devamını Göster
Özet
The purpose of this study was to investigate the effect of heavy alcohol consumption on peroxidation status in apolipoprotein B-containing lipoproteins (LDL+VLDL) and plasma as well as plasma homocysteine (HC) levels in patients with chronic alcoholism who drank raki. a national Turkish beverage. For this reason, endogenous diene conjugate (DC) and lipid hydroperoxide (LOOH) levels and lag phase, maximum DC formation and propagation rate following copper induction were measured in apolipoprotein B-containing lipoproteins (LDL+VLDL) isolated by precipitation with dextrane sulfate and MgCl2 from plasma. In addition, serum malondialdehyde (MDA), DC, HC, folate and vitamin B12 levels as well as paraoxonase activity were determined. Serum MDA and DC levels were higher in heavy raki drinkers compared to control subjects. Significant increases in endogenous DC and LOOH levels in LDL+VLDL together with shortened lag phase were also observed in patients. In addition, HDL-cholesterol, HC and vitamin B12 levels and HDL-associated paraoxonase activity were found to be higher, but folate levels to be lower in serum of heavy raki consumers. In conclusion, our results indicate that increases in LDL+VLDL oxidizability and plasma HC levels may enhance the susceptibility to vascular diseases in heavy raki drinkers.
Anahtar Kelimeler
Alcoholism | Homocysteine | Raki drinkers
Makale Türü Açık Erişim Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Journal of Nutritional Science and Vitaminology
Dergi ISSN 0301-4800 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 04-2005
Cilt No 51
Sayı 2
Sayfalar 99 / 103
DOI Numarası 10.3177/jnsv.51.99
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
SCOPUS 6
Increased LDLVLDL oxidizability and plasma homocysteine levels in chronic alcoholic patients

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